Complete Guide to All Runewords in Diablo 4: Featuring Vessel of Hatred & Usage Tips

Runewords have made their return in Diablo 4 with the new Vessel of Hatred DLC. But how exactly do they function, and what abilities do the different Runes provide?

Veterans of Diablo 2 will remember that Runewords were a key mechanic for acquiring unique abilities. In Diablo 4, every Rune acts as a distinct item that can be fitted into the socket of either weapons or armor. Each Rune contains a specific term, and when multiple Runes are combined within a single piece of equipment, they form unique Runewords, each bestowing special powers.

While experimenting with various Runes can be enjoyable, players often want to understand the benefits of each Runeword combination. That’s why we’ve compiled all the details you need right here.

How to Utilize Runewords?

To effectively use Runewords, you’ll need to combine Runes from two opposing categories: Runes of Ritual and Runes of Invocation. Runes of Ritual are characterized by their glowing yellow symbols, whereas Runes of Invocation bear purple symbols. The yellow Runes guide you in completing specific tasks, while the purple Runes indicate the effects produced by mixing the two types.

For instance, consider a yellow Rune named “Zan” that requests you to activate your Ultimate Skill, while a purple Rune called “Ceh” grants the ability to summon a wolf companion, regardless of whether you play as a Druid.

By combining them, you create the Runeword ZanCeh.

your class typically does not possess

Remember that to activate your Runeword ability, you’ll need a resource referred to as “Offering.” This resource is generated by your Rune of Ritual and consumed when your Rune of Invocation activates its effect. Thus, it’s essential to track your Offering levels—if they deplete, you’ll have to wait for them to regenerate before your Runeword can trigger again.

Some Runes can produce more Offering than they use, allowing for an interesting mechanic where skills can be repeated multiple times without cooldown delays.

Runes of Ritual determine the actions that must be performed.

Complete List of Runes in Diablo 4

Here’s a comprehensive overview of every Rune of Ritual in Diablo 4, along with the triggers for their abilities:

Rune	Offering Cost	Trigger
Body	10	Achieve a Lucky Hit with up to 100% chance against Injured enemies.
Bac	50	Move a distance of 5 meters.
Cem	50	Execute Evade skill.
Cir	25	Cast the same non-channeled Skill three times consecutively.
Sound	1000	Become Injured or affected by Crowd Control.
From you	2	Lose 1% of your health.
Lith	25	Remain stationary for less than a second.
Money	10	Cast a skill after performing a movement.
Neo	300	Inflict damage after a duration of 5 seconds without taking damage.
Night	5	Apply a Crowd Control effect that isn’t Slow or Chill.
little	2	Spend 5% of your Maximum Resource.
For that	25	Cast a non-Channeled Core Skill.
Ur	10	Your Minion or Companion either kills an enemy or is defeated.
Score	150	Channel power from another Class.
Yes	100	Consume a Healing Potion.
Yul	50	Cast a Skill that has a cooldown.
I will	150	Activate an Ultimate Skill.

Runes of Invocation activate the abilities once the Runeword is completed.

Below is a list of every Rune of Invocation found in Diablo:

Rune	Offering Cost	Ability
Ceh	100	Summon a Spirit Wolf to attack enemies for 8 seconds.
Eom	100	Reduce all active Cooldowns by 0.25 seconds.
Even	25	Gain a 2.5% Critical Strike Chance for 5 seconds, up to a max of 25%.
Yes	500	Replace your next Evade with the Sorcerer’s Teleport, allowing for greater distance and damage while becoming Unstoppable.
Get	500	Invoke the Spiritborn’s Vortex, causing damage and drawing enemies close.
Lac	800	Call upon the Barbarian’s Challenging Shout to reduce incoming damage.
Lum	5	Restore 1 Primary Resource.
Of	100	Gain a protective shadow from the Rogue’s Dark Shroud, mitigating damage for each shadow.
Courage	150	Acquire a shadow from the Rogue’s Dark Shroud, which reduces damage taken.
Down	700	Invoke the Rogue’s Countering Concealment, enhancing Dodge Chance, Movement Speed, Unstoppable trait, and Stealth.
Ohm	500	Activate the Barbarian’s Enhanced War Cry to boost Movement Speed and damage output.
Ono	25	Invoke the Druid’s Dancing Bolts, seeking out and damaging foes.
Go	400	Your next non-Basic Skill utilizes all Primary Resources for a potential damage increase of 100%.
Via	400	Summon the Druid’s Earthen Bulwark, providing a protective Barrier.
Of	100	Invoke the Spiritborn’s Pestilent Swarm, dealing damage to enemies.
Answer	100	Invoke the Necromancer’s Abhorrent Iron Maiden, countering damage from foes while healing when enemies die.
Tec	100	Call upon the Barbarian’s Earthquake to deal area damage.
Thul	400	Summon the Sorcerer’s Mystical Frost Nova, inflicting Freeze and Vulnerable states.
Ton	25	Evoke the Sorcerer’s Meteorites to damage foes.
Again	100	Use the Rogue’s Stun Grenades for Stunning and damaging enemies.
Tzic	250	Evoke the Spiritborn’s Concussive Stomp, dealing damage and Knocking Down enemies.
Vex	400	Gain +3 to all Skills for 5 seconds.
What	100	Invoke the Necromancer’s Horrid Decrepify, slowing enemies and augmenting damage, allowing for Executions.
Solution	200	Increase your Maximum Life by 20% for 4 seconds.
Khan	700	Your next Skill activation will be a guaranteed Critical Strike and Overpower.
Yom	500	Invoke the Druid’s Petrify, Stunning enemies and raising your Critical Strike Damage against them.
Zec	200	Decrease your active Ultimate cooldown by 4 seconds.

Where to Find Runes?

Fortunately, Runes can be discovered throughout the game world, just like other loot items. Our findings indicate that higher difficulty levels tend to yield more drops.

We also observed an enhanced drop rate for Runes during Helltide events, when battling Elite opponents, and while participating in Seasonal or endgame content.

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