Hardest Bosses in Diablo 4 & How to Beat Them

Even if you believe you are fully prepared for the harshness of Sanctuary, the bosses in Diablo 4 are on a completely different level. Blizzard has incorporated them into the story, making them a significant threat if you are not familiar with their unique abilities.

To those seeking a challenge or looking to obtain Legendary Aspects or Unique Items, below is a compilation of Diablo 4’s most difficult bosses and strategies for defeating them.

Hardest Diablo 4 Bosses: Locations and Materials

Hardest Main Campaign Bosses in Diablo 4

Blood Bishop

Even if the Blood Bishop isn’t part of the main campaign, it’s a powerful boss to level stats up.

• The Chamber of Martyrs can be found in the Hollowed Ossuary Dungeon, located in the Fractured Peaks.

The Blood Bishop is an elective boss encountered during the course of Diablo 4’s campaign. As a vampiric adversary, be cautious of his long-range attacks. It is advised to reach a minimum level of 14 before attempting to defeat him.

There are four abilities that are repeated and should be watched out for. One of the boss’ abilities is the Single-Projectile, which involves throwing an energy blast directly at your character. However, it is easily avoidable. Another ability, the Vollet Projectile, may be more challenging as Blood Bishop will summon a small cloud and unleash multiple energy blasts.

In addition, Bloody Bishop employs the use of Blood Clot Mines, which generate four red orbs that detonate after a brief period of time. His ultimate special move, Bloodsucker, involves the boss grabbing and draining your blood to replenish his own health.

The main focus of the Blood Bishop is spell casting, so caution should be taken when dealing with his rapid projectiles. The most effective method of defeating him is to constantly keep moving and swiftly eliminate any Blood Clot Mines obstructing the arena. When facing him alone, it is advisable to take cover behind pillars and wait for the opportune moment to attack.

Astaroth the Charred Duke

Astaroth is the main boss of Act 2 and will present quite a challenge.

• The ruins of Cerrigar can be found in Act II of the Scosglen region.

Astaroth, who can be encountered in the earlier stages of the Diablo 4 campaign, will be revived by Lilith in Act 2 and can be seen mounted on a massive three-headed Hellhound.

Astaroth’s three primary attacks can cause significant damage if you are caught off guard. His Staff Swing has the power to bring you down and drain your entire life with just one strike. He is also capable of unleashing Fire Breathing, which inflicts continuous damage on any character it touches. Additionally, the boss has the ability to summon Fire Balls that descend from above with little warning.

To successfully battle Astaroth in Diablo 4, it is crucial to continuously move, strike from behind, and utilize an Elixir of Fire Resistance.

To locate Astaroth in Diablo 4, simply undertake the Worlds Burns quest in Cerrigar (Scosglen).

Elias Hatred’s Remnant

Elias can be seen during the first cutscene of Diablo 4.

• The Black Tomb of Sankekur (Act 3) and the On the Precipe Quest (Act 5) are both locations where this can be found.

Lilith’s preferred boss demon in Diablo 4 is Elias. As he is immortal, you will encounter him in both Act 3 and Act 5 of the main campaign.

During the initial battle, Elias will possess a standard health bar and utilize Tracking Bolts as homing projectiles. It is crucial to evade his Area-of-Effect attacks as they can impede your movement and leave your character open to attacks. To defeat him, prioritize close-range attacks to inflict damage.

After exhausting his energy, a cutscene will interrupt the fight and display a dialogue between Lilith and the protagonist.

After the cinematic ends, you will find out that Elias is still alive and prepared for another battle. The boss will then call upon a demon known as the Champion of Lilith, who will join forces with him and conjure powerful Ground Pentagrams. Just as you think you are gaining the upper hand, Elias will bring in another Champion to aid him. It is advised that you defeat these demons before attempting to take on the main boss.

Sorcerers and Necromancers are the most effective classes against Elias, as they have the ability to deal melee damage with summons while also avoiding the demon boss’s reach.

Duriel Lord of Pain

Duriel will use his entire environment to trap Wanderers.

• Location: The Walls Shake in Caldeum, during Act 6 (Kehjistan).
  • Summon materials:
    • Uber: Sandscorched Shackles x2, Pincushioned Dolls x2 (World Tier IV)
    • Tormented: Sandscorched Shackles x6, Pincushioned Doll x6, Stygian Stone x1.

Duriel is the final boss in Diablo 4 before the Wanderers enter Hell. While he does possess a few long-range attacks, his battle primarily consists of three melee phases. This demon has a total of four abilities at his disposal to defeat any Wanderer who dares to challenge him.

• The Eater of Worlds, Duriel, will grab players and pull them into his stomach after performing a stomping attack. The impact of this attack can potentially deplete half of the Wanderer’s health, depending on their defenses.
• Burrow: Duriel will tunnel into the ground to avoid the player’s attacks. The craters he creates will remain in the battlefield and can ensnare players during combat.
• Plague Maggots: As they burrow into the ground, a dozen maggots will hatch and swarm any player in the vicinity. Although this attack inflicts low-level damage, it can be quite troublesome to be caught between craters.
• Stab: Duriel possesses massive crab arms that can inflict moderate damage when striking the Wanderers.
• The demon known as Belly Belch will expel stomach acid in front of him, resulting in Poison damage.

It can be challenging to strike Duriel due to his ability to Burrow and swarm you with Plague Maggots. Your best course of action is to use Area-of-Effect abilities to trap or slow him down, allowing you to land a few powerful attacks.

The Butcher

The Butcher has been featured in every Diablo game.

• The location of this item is random and it can appear in any Dungeon.

The Butcher is not a typical boss and it is possible to complete the game without encountering him. However, if you happen to be in his vicinity, you will hear him shouting “Fresh Meat!”and he will not allow you to escape.

The following are the attacks used by The Butcher:

• Cleaver/Sickle Swing: The Butcher’s primary form of melee attack involves swinging its weapons, which can include cleavers or sickles.
• Hook: The villain shoots out a hook towards your character, reeling you in and causing the Stun status effect.
• The Butcher will use Headbutt to inflict damage and Stun, by headbutting you.
• The Butcher’s roar will release a burst of blood-red energy, causing you to be affected by the Slow effect.
• Action: The boss will charge towards you, causing damage and applying the Stun effect from a distance.

Despite the challenge of facing an overleveled Butcher, it is rare for players to defeat him on their initial playthrough. The key to success lies in having a robust build capable of withstanding attacks and providing ample mobility.

It is crucial to be capable of inflicting substantial damage to a single target, as he will constantly attack and use Stun abilities, leaving very little room to catch your breath.

Lilith Mother of Sanctuary

Lilith will go through two transformations before being defeated.

• The location is Echo of Hatred (Fractured Peaks).

As anticipated, Lilith serves as the final and most challenging boss in the main campaign of Diablo 4. During the battle, she will shift between two stages, beginning with her formidable form as the “Creator of Sanctuary”and utilizing numerous area-of-effect attacks.

During the second stage, her form will transform into the “Daughter of Hatred”where not only her damage will be elevated, but she will also wreak havoc on the surrounding environment. It is advised to reach at least level 45 before confronting her.

During her initial form, Lilith will release a total of four distinct attacks:

• Summoning Champions: The boss will call forth powerful demons, referred to as Champions of Chaos, to assault the player.
• During the “Hell Dive”move, Lilith will fly towards the players and land with great force in the middle of the arena, causing significant damage.
• Demon Cross: By drawing two intersecting lines on the ground, the arena will be engulfed in a ring of flames.
• The demon’s basic melee attack, known as “Spinning Slice”, involves two spinning strikes.

To successfully defeat Lilith in her “Creator of Sanctuary”form, it is important to pay attention to her minions and use Area-of-Effect attacks to control them. Additionally, equipping potions or items that enhance Evasion can aid in dodging her constant charges.

Upon completing this initial stage, Lilith will assume her complete demonic form and acquire a fresh array of skills:

• Shadow Flight: Lilith takes flight, moving sideways and leaving behind a trail of shadow mist that corrupts the areas she passes through.
• During the battle, the demon will gradually destroy sections of the arena.
• Corrupted Growths: Unusual growths will appear in the arena, eventually detonating and causing damage.

Even if you are unable to prepare for the second stage, remember that Lilith will not replenish her potions when she dies for the first time. In her second form, Lilith’s attacks will be more powerful, so be sure to act quickly and avoid her new abilities to prevent a swift defeat.

Most challenging endgame bosses

Wandering Death, Death Given Life

Wandering Death is just one of the three demons that spawn randomly on the map.

• Locations: Caen Adar in Scosglen, Saraan Caldera in the Dry Steppes, The Crucible in Fractured Peaks, Seared Basin in Kehjistan, or Fields of Desecration in Hawezar.

In addition to the main campaign bosses, Diablo 4 also features three PvE demons that may appear unpredictably in Sanctuary. Among them is Wandering Death, who possesses a total of seven techniques that can easily overpower any player attempting to defeat it solo.

• Death Crater: Wandering Death will cause a massive explosion that creates a crater within five seconds, potentially trapping players. The number of these craters will increase as the fight continues.
• Death Pound: The boss will slam the ground in front of him, causing a wave of spikes to emerge. As the fight progresses, this attack will become increasingly powerful.
• Death Shout: As the name suggests, this demon will let out a deafening scream, creating a shockwave that ripples across the entire battlefield.
• As the demon’s health decreases, several tornadoes will form and knock players to the ground.
• Death Beam: The most powerful attack of Wandering Death, this beam is cast from his hands and will multiply in strength as he sustains damage.

Facing Wandering Death is a difficult task, which is why it is crucial to pay attention to the green circles that appear on the ground before he executes a Death Pound attack. As the battle progresses, these circles will increase in size, making it essential to focus on movement when confronting the demon.

Andariel: Maiden of Anguish

Andariel is one of the bosses that returns from Diablo 2.

• Venue: Scouring Sands’ Hanged Man’s Hall, located in Kehjistan.
• Summon materials:
  • Uber: Sandscorched Shackles x2, Pincushioned Dolls x2 (World Tier IV)
  • Tormented: Sandscorched Shackles x6, Pincushioned Doll x6, Stygian Stone x1.

Andariel, the boss of Diablo 4, has multiple phases that slightly prolong the battle. Although initially bound, she will eventually break free and unleash her extra limbs to ruthlessly attack.

During the initial phase of the battle, she will be restrained to a cross. From this position, she has the ability to summon three Rune Chains which will impede your movement and limit your space. If you become trapped, keep in mind that the chains can be easily destroyed with just a few strikes.

In addition, this boss will summon Flying Demon heads that may occasionally target you and inflict minor to moderate damage. Once the heads have been released, Andariel will levitate and reappear on the opposite side of the screen.

After the initial two stages, Andariel will unleash her Stream of Shadow attack, damaging anyone who enters its zone. Additionally, she will defend herself with Wake of Shadow against any sneak attacks. Moreover, the demon can use her chains to strike with Chain Lash.

Andariel, in true this-is-not-even-my-final-form fashion, will become restless once her health drops to 90%. She will crouch down, break free from her restraints, and sprout a pair of scorpion-like appendages. This is the moment to be cautious of her Hair Sling attack, where she will fling her hair and chains forward, unleashing a wave of shadow damage in front of her.

If you have managed to survive everything so far, the boss demon will additionally conjure up a Sandstorm to block your movement in the surrounding area.

To successfully defeat Andariel, it is important to pay attention to her current stage in the fight. When she is shackled, the demon boss is likely to rely heavily on Area-of-Effect attacks. These attacks can be anticipated and her cooldown periods provide a window of opportunity to inflict significant damage.

Remember that the demon is quite fast but can be easily staggered when she frees herself.

Avarice The Gold Cursed

This World Boss attacks with a Mallet and a huge Treasure Chest chained to his arm.

• Location: Seared Basin (Kehjistan), The Crucible (Fractured Peaks), Saraan Caldera (Dry Steppes).

Avarice, one of the main World Bosses, cycles through a variety of melee attacks. Throughout its three different phases, the demon can select from numerous powerful attacks that cause significant physical damage and have a wide reach. These include:

• Spin Attack: Avarice will use the Treasure Chest he carries as a weapon, spinning it to hit everything in a 360° area. The only way to avoid it is by moving towards the center, where the chain is located, or by moving out of the boss’s reach.
• Portal Charge: The World Boss possesses the ability to teleport through a golden portal at regular intervals and charge through it, resulting in almost instantaneous death. This attack follows a straight path, making it simple to dodge.
• Mallet Thrust: In its subsequent stage, the demon will swing its mallet, causing damage to all enemies in a cone-shaped area.
• Pillars of Gold: The power of greed will manifest in the form of towering columns of gold, altering the battlefield. These structures can be utilized to ensnare and incapacitate players, or can be shattered, unleashing a torrent of molten gold that inflicts significant harm.
• In its third phase, the demon known as Golden Vomit will start to expel pools of gold onto the arena. Standing in these pools can prove fatal for players and, when combined with the pillars, they become incredibly difficult to avoid.
• Ground Stomp: Avarice frequently stomps the ground before conjuring pillars or spewing forth a stream of golden vomit. This is his way of pulling players towards him and trapping them.

The most effective method for inflicting damage on Avarice is to stagger him. Keep an eye on the bar below his health bar – when it turns blue, the World Boss will be more susceptible to damage. However, Avarice will also call forth Gold Goblins to entice you, so exercise caution and refrain from being lured by greed. Maintain your focus on attacking Avarice.

Ashava The Pestilent

• Venue: The Crucible at Fractured Peaks.

Along with being one of Sanctuary’s World Bosses, Ashava is known for her attacks that consist of two parts and inflict poison damage.

Ashava’s Double Swipe involves a 360° sweep through the ground, followed by a second sweep in a 180-degree arc. She also utilizes her Leap attack, which knocks opponents down and inflicts significant damage. Her Ground Pound creates powerful waves that draw in her target before delivering a deadly strike.

Two of the demon’s lesser abilities include Acid Spit, in which she spits out three globs of poison that remain on the battlefield for 20 seconds, and Bite, a close-range attack that hits four times.

Evading Ashava’s attacks and staying behind her is the most effective strategy for defeating her. Additionally, it is advised to have equipment that can protect against her Poison attacks.

How to Defeat Dark Master Lord Zir in Diablo 4

Lord Zir was introduced in Season of Blood.

• The location of the Ancient’s Seat of The Darkened Way can be found in the Gale Valley of the Fractured Peaks.
• Summon materials:
  • Normal: Exquisite Blood x9 in World Tier 4.
  • Tormented: Exquisite Blood x27, Stygian Stone x1.

To successfully defeat Lord Zir, it is crucial to execute swift and precise attacks and evasions, as a single mistake during the encounter could result in significant damage to your health bar.

The main techniques utilized by Dark Master Lord Zir are:

• Blood Rain: As soon as you spot Lord Zir soaring and flapping his wings, be prepared to maneuver around the arena as he will unleash a deluge of blood and pools of blood.
• Claw of Blood: When Lord Zir summons his claws of blood, they will take on a scythe-like shape. Be sure to either move behind him during his wind-up or dodge away, as this attack can cause significant damage.
• Wing Blast: After inflicting enough damage, he will teleport away from you and launch wing blast attacks in your direction. It is crucial to dodge these attacks as they can cause significant damage.

During the course of the battle, Lord Zir will begin summoning minions and adds, which may pose a challenge for melee or solo players. It is important to eliminate these enemies and avoid the incoming blood wave attacks before refocusing on Lord Zir.

As you steadily decrease his HP, he will begin to increase the speed and strength of his attacks. Therefore, it is advisable to refrain from using an excessive amount of health potions at the start of the battle.

Gregory, the Galvanic Saint

Grigoire, the Galvanic Saint is a great endgame boss to farm Mythic Uniques.

• The Hall of the Penitent can be found in Dindai Flats, specifically in the Dry Steppes.
• Summon materials:
  • Normal: 5x Living Steel in World Tier 4 or 2x Living Steel in World Tier 3.
  • Torment: 15x Living Steel in World Tier 4, and Stygian Stone x1.

Grigoire’s attacks primarily involve electricity and will span across a large portion of the arena. He will also utilize any potential hazards in the environment and will not allow you to seek refuge from his area-of-effect abilities.

The following are Grigoire’s complete set of skills:

• Phase 1:
  • Thunderous Entrance: He’ll enter the fight calling down lightning onto square panels a few at a time.
  • Lightning Call: He slams his large mace to the ground and calls lightning down to circular areas around the battlefield.
  • Dancing Bolts: He swings his mace toward you and shoots out multiple balls of lightning that travel outwards.
  • Dancing Bolts – Surround: He swings his mace toward you and shoots out multiple balls of lightning in all directions that travel outwards.
• Phase 2:
  • Red Lanes: He summons red lightning rods around the battlefield and courses lightning currents through them to trap you and damage you if you touch them.
  • Saintly Call: He summons multiple Knight Penitents to help him.
  • Red Lanes – Thunderous Re-entrance: While electric currents course through the lightning rods, he will teleport out of the battlefield and then electrify most panels of the battlefield as he re-enters.

How to Beat The Beast in Ice in Diablo 4

The Beast in Ice has three phases you need to beat before defeating it.

• The Glacial Fissure Dungeon (located in the Fractured Peaks) is where it can be found.
• Summon materials:
  • Normal: Distilled Fear x9 in World Tier 4.
  • Torment: Distilled Fear x27, Stygian Stone x1.

The Beast in Ice has a total of three phases, during which it alternates between unleashing potent melee strikes and area-of-effect attacks that may inflict the Frozen status and cause significant harm. The following are all of its abilities:

• Phase 1
  • Icy Breath: The Beast in Ice will inhale multiple ice crystals that multiply after they shatter.
  • Frostquake: After roaring, the boss slams the ground generating multiple frost pools.
  • Frozen Strikes: The Beast slashes with his sword and creates ice crystals.
  • Leap Attack: Rising into the air, The Beast slams down dealing damage in a large area, and releasing several Ice crystals.
• Phase 2
  • Icy Hail: The Beast leaves its blade stuck into the ground and channels multiple icy explosions that release icy waves moving towards you.
• Phase 3:
  • Enhanced Icy Hail: Besides its other attacks, The Beast will channel multiple ice explosions, but you’ll get double icy waves moving towards you.

To effectively combat The Beast in Ice, it is recommended to utilize a build with a high level of mobility. This will allow you to easily evade any AoE attacks and strategically land a powerful strike. It is advisable to maneuver behind the boss and steer clear of any circular ice zones that indicate the location of its attacks.

The majority of bosses in Diablo 4 offer a thrilling test for your preferred builds. However, if you’re not interested in gathering materials or exploring Sanctuary in search of a World boss, there are alternative options like the Pit or the Gauntlet available to you.

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