Ranking the 10 Most Powerful Immortal Anime Villains

For years, audiences have been captivated by immortal anime villains, drawn to their boundless power and relentless presence.

For these characters, being among the strongest immortal anime villains transcends mere existence; it often gifts them with otherworldly powers, making them virtually unbeatable. Their immortality stems from a variety of sources, including ancient curses and divine interventions.

This article will explore the realm of immortal anime villains, ranking the top ten most formidable amongst them.

Disclaimer: This article represents the author’s views and opinions.

10 Most Powerful Immortal Anime Villains, Ranked

10) Naruto

Hidan's form after performing his ritual (Image via Studio Pierrot) — Hidan’s form after performing his ritual (Image via Studio Pierrot)

In the Naruto series, Hidan is a member of the infamous Akatsuki organization. His devotion to the deity Jashin has granted him immortality, enabling him to survive fatal injuries and making him a fearsome adversary in combat. His primary ability is a ritualistic killing technique where he uses his own blood to create a link with his opponent, allowing him to inflict the same injuries on them as he does to himself, effectively turning him into a living voodoo doll.

However, he ranks the lowest on this list of immortal anime villains due to his lack of versatility and dependence on specific conditions for his powers. His defeat by Shikamaru Nara, who outsmarted him and buried him alive, showcases his vulnerabilities and the limitations of his immortality.

9) Zeref Dragneel (Fairy Tail)

Zeref as seen in the anime (Image via Satelite, A-1 Pictures)

Zeref Dragneel, the dark wizard from Fairy Tail, is one of the most tragic and multi-dimensional immortal anime villains. His life is characterized by loneliness and despair, stemming from his curse of immortality and a range of devastating magic. He possesses enormous power, as everything he cares for meets its end due to his Ankhseram curse. Zeref’s vast knowledge of magic and immortality make him a powerful foe who can withstand harm.

He has the capability to control life and death, summon powerful demons, and perform ancient forbidden magic. His most notable creation, the Etherious Natsu Dragneel (E.N.D), was designed to kill him. Despite his vast magical abilities, Zeref’s emotional turmoil and longing for death detract from his effectiveness as one of the most powerful immortal anime villains, transforming his immortality into a curse.

8) Griffith (Berserk)

Griffith as seen in Berserk 2016 (Image via Millepensee, GEMBA)

Griffith, later known as Femto, is a deeply complex and morally ambiguous villain. He is the charismatic and determined leader of the Band of the Hawk, driven by his desire to establish his own kingdom. His transformation into a demonic entity grants him immortality and immense power, yet it comes at a significant price.

After becoming Femto, Griffith joins the God Hand, a group of immensely powerful demonic beings capable of manipulating fate and dark energies. His powers in this form exceed those of an ordinary human, enabling him to manipulate time and reality.

7) Muzan Kibutsuji (Demon Slayer)

Muzan as seen in the anime (Image via Studio Ufotable)

The progenitor of all demons in Demon Slayer, Muzan Kibutsuji, is a formidable and cunning foe. As the first demon, he wields incredible regenerative capabilities, shape-shifting, and tremendous strength. He can convert humans into demons using his blood, and his loyal followers obey him without question. Muzan’s cunning nature and adaptability pose a persistent threat to humanity.

With his immortality and ability to regenerate, he becomes nearly invincible in fights. His shape-shifting capabilities also allow him to blend into human society while recovering from almost any injury. Muzan is a master manipulator, making him one of the most feared immortal anime villains, though his inability to endure sunlight remains his ultimate weakness.

6) Zamasu (Dragon Ball Super)

Zamasu as seen in Dragon Ball Super (Image via Toei Animation)

One of the most dangerous immortal anime villains in Dragon Ball Super is Zamasu, a former Kai who turned to evil. His desire for immortality drove him to seek the Super Dragon Balls, fueled by his belief in the superiority of gods over mortals.

After achieving his goal, Zamasu fuses with Goku Black to create Fused Zamasu, a being of god-like strength and immortality. Fused Zamasu boasts immense power, speed, and durability, along with the ability to manipulate energy and unleash potent attacks.

Thanks to his immortality, he can recover from any injury and engage in battles without fatigue. Zamasu represents one of the strongest immortal anime villains, capable of taking on several formidable opponents simultaneously because of his divine powers and fusion with Goku Black.

5) Dio Brando (JoJo’s Bizarre Adventure)

Dio as seen in the anime (Image via David Production)

Dio Brando, the iconic vampire from JoJo’s Bizarre Adventure, stands out as one of the most famous and powerful immortal anime villains. Through a stone mask, Dio acquires immortality and gains The World, a Stand with the ability to stop time. His extraordinary strength, brutality, and cunning make him a legendary antagonist in the series.

Dio possesses superhuman strength, speed, and regenerative abilities derived from his vampiric nature. With his Stand, The World, he can halt time momentarily, providing him with a significant strategic advantage. Dio’s intuitive planning and strategic prowess secure his place among the strongest immortal anime villains.

4) Father (Fullmetal Alchemist: Brotherhood)

Father [Homunculus] as depicted in the anime (Image via Studio Bones)

Father, the main antagonist of Fullmetal Alchemist: Brotherhood, is a homunculus who strives to become a deity. His immense alchemical manipulation prowess, soul-absorbing capabilities, and ability to heal from any injury establish him as one of the strongest immortal anime villains.

As a being created from the essence of a powerful alchemist, Father possesses profound knowledge of alchemical principles, which he wields with devastating impact. His abilities include creating and commanding homunculi, each gifted with unique talents.

He can manipulate the reality’s very fabric using alchemy to reshape his surroundings. His ultimate aim is to absorb the essence of God, becoming an all-powerful being capable of ruling the universe. Father’s confluence of knowledge and insatiable hunger for power marks him as one of the most potent immortal anime villains.

3) Aizen (Bleach)

Aizen after merging with the Hogyoku (Image via Studio Pierrot)

Sōsuke Aizen, the former captain of the 5th Division in Bleach, ranks among the most cunning and powerful immortal anime villains. After merging with the Hōgyoku, Aizen acquires immense spiritual power and immortality. His mastery of Kido and combat, combined with his ability to manipulate others using Kyoka Suigetsu, his Zanpakuto, make him a nearly unbeatable opponent.

His immortality and immense spiritual presence establish Aizen as a formidable foe in combat. Utilizing his Zanpakuto, Kyoka Suigetsu, he can craft perfect illusions, distorting his opponent’s perceptions which renders him unpredictable. This strategic advantage allows Aizen to outmaneuver and outsmart his enemies with ease.

2) Kaguya Otsutsuki (Naruto)

Kaguya as seen in the anime (Image via Studio Pierrot)

Kaguya Ōtsutsuki, hailed as the progenitor of chakra in the Naruto universe, embodies god-like power and immortality. Boasting colossal chakra reserves and dimension manipulation, she is a nearly unbeatable combatant, outclassing all other characters in strength and skill.

Kaguya possesses the ability to create and manipulate dimensions, alter reality, and unleash devastating chakra-based attacks. With her Byakugan and Rinne Sharingan, she can cast potent genjutsu and maintain unparalleled perception. As one of the most formidable immortal anime villains, her regeneration abilities make her a challenging opponent in battle.

1) Yhwach (Bleach)

Yhwach as seen in Bleach: TYBW (Image via Studio Pierrot)

Yhwach, the Father of all Quincy and the main antagonist of Bleach’s Thousand-Year Blood War arc, is hailed as the most powerful immortal villain. His near-omnipotent abilities pose a significant threat due to his capacity to absorb and disperse souls and control the future. Yhwach’s unique ability, The Almighty, allows him to foresee and alter events, rendering him nearly invincible.

Throughout the Thousand-Year Blood War arc, Yhwach grows stronger by acquiring the powers of formidable beings, thus exploiting their abilities for his gain. To defeat him requires the combined efforts of several powerful characters capable of recognizing a weakness in his abilities. Yhwach’s tremendous power, immortality, and future-manipulating capabilities solidify his position as the strongest immortal anime villain.

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